/* =============================================================
   Alzheimer's disease research disclosure — shared styles
   Palette grounded in AD histopathology:
   oxblood ≈ eosin / Congo-red stain; viridian ≈ apple-green birefringence
   ============================================================= */
:root{
  --paper:#ffffff; --paper-2:#f2f6f6; --ink:#16262e; --ink-soft:#4c5c64;
  --oxblood:#0e8a83; --oxblood-2:#0b6f69; --viridian:#123c48;
  --stone:#7b8a90; --rule:#e2eaec; --focus:#0e8a83; --maxw:1120px;
}
*{ box-sizing:border-box; }
html{ scroll-behavior:smooth; }
@media (prefers-reduced-motion: reduce){ html{ scroll-behavior:auto; } }
body{
  margin:0; background:var(--paper); color:var(--ink);
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:18px; line-height:1.62;
  -webkit-font-smoothing:antialiased; text-rendering:optimizeLegibility;
}
::selection{ background:var(--viridian); color:#fff; }
a{ color:var(--oxblood); text-underline-offset:3px; text-decoration-thickness:1px; }
a:hover{ color:var(--oxblood-2); }
:focus-visible{ outline:2px solid var(--focus); outline-offset:3px; border-radius:2px; }
img{ max-width:100%; height:auto; display:block; }
.wrap{ max-width:var(--maxw); margin:0 auto; padding:0 28px; }

/* ---------- top navigation ---------- */
.topbar{
  position:sticky; top:0; z-index:50; background:rgba(242,243,239,.86);
  backdrop-filter:saturate(1.1) blur(8px); border-bottom:1px solid var(--rule);
}
.topbar .wrap{ display:flex; align-items:center; gap:22px; height:60px; }
.brand{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:14px;
  letter-spacing:.02em; color:var(--ink); text-decoration:none; white-space:nowrap;
}
.brand .mark{ color:var(--oxblood); }
nav.primary{ margin-left:auto; }
nav.primary ul{ list-style:none; display:flex; gap:6px; margin:0; padding:0; overflow-x:auto; scrollbar-width:none; }
nav.primary ul::-webkit-scrollbar{ display:none; }
nav.primary a{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; font-weight:500;
  color:var(--ink-soft); text-decoration:none; padding:7px 11px; border-radius:6px; white-space:nowrap;
}
nav.primary a:hover{ background:var(--paper-2); color:var(--ink); }
nav.primary a[aria-current="page"]{ color:var(--oxblood); background:var(--paper-2); }

/* ---------- hero ---------- */
.hero{ position:relative; overflow:hidden; border-bottom:1px solid var(--rule); }
.hero .plaques{ position:absolute; inset:0; z-index:0; opacity:.5; pointer-events:none; }
.hero .wrap{ position:relative; z-index:1; padding:78px 28px 70px; }
.kicker{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; font-weight:500;
  color:var(--viridian); display:flex; align-items:center; gap:10px; margin:0 0 22px;
}
.kicker::before{ content:""; width:26px; height:2px; background:var(--viridian); display:inline-block; }
h1.title{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:400; font-size:clamp(2.5rem, 6.2vw, 5rem);
  line-height:1.02; letter-spacing:-0.015em; margin:0 0 8px; max-width:16ch;
}
h1.title em{ font-style:italic; color:var(--oxblood); }
.subtitle{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:300; font-style:italic;
  font-size:clamp(1.15rem, 2.4vw, 1.6rem); color:var(--ink-soft); margin:0 0 30px; max-width:34ch;
}
.standfirst{ max-width:60ch; font-size:1.12rem; color:var(--ink); margin:0 0 34px; }
.byline{
  display:flex; flex-wrap:wrap; align-items:baseline; gap:6px 16px;
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:14px; color:var(--stone);
  border-top:1px solid var(--rule); padding-top:20px; max-width:60ch;
}
.byline .who{ color:var(--ink); font-weight:600; }
.byline .mono, .mono{ font-family:"IBM Plex Mono", monospace; font-size:12.5px; }

/* one restrained page-load reveal */
.reveal{ opacity:0; transform:translateY(14px); animation:rise .9s cubic-bezier(.2,.65,.3,1) forwards; }
.reveal.d1{ animation-delay:.05s; } .reveal.d2{ animation-delay:.16s; }
.reveal.d3{ animation-delay:.27s; } .reveal.d4{ animation-delay:.38s; }
@keyframes rise{ to{ opacity:1; transform:none; } }
@media (prefers-reduced-motion: reduce){ .reveal{ animation:none; opacity:1; transform:none; } }

/* ---------- section scaffolding ---------- */
section.block{ padding:72px 0; border-bottom:1px solid var(--rule); }
.sec-head{ display:flex; align-items:baseline; gap:16px; margin:0 0 32px; }
.sec-index{ font-family:"IBM Plex Mono", monospace; font-size:13px; color:var(--oxblood); padding-top:.55rem; flex:none; }
.sec-head h2{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:500; font-size:clamp(1.7rem, 3.6vw, 2.4rem);
  line-height:1.1; letter-spacing:-0.01em; margin:0;
}
.sec-head .lede{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-style:italic; font-weight:300; color:var(--ink-soft);
  font-size:1.05rem; margin:8px 0 0; max-width:56ch;
}

/* ---------- researcher / cv ---------- */
.cv-grid{ display:grid; grid-template-columns:minmax(0,1.55fr) minmax(0,1fr); gap:48px; align-items:start; }
@media (max-width:820px){ .cv-grid{ grid-template-columns:1fr; gap:36px; } }
.prose p{ margin:0 0 1.1em; }
.prose p:last-child{ margin-bottom:0; }
.facts{ background:var(--paper-2); border:1px solid var(--rule); border-radius:10px; padding:26px 26px 28px; }
.facts h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 16px; }
.facts dl{ margin:0; display:grid; grid-template-columns:auto 1fr; gap:11px 16px; }
.facts dt{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; color:var(--stone); }
.facts dd{ margin:0; font-size:15px; }
.facts .patent{ margin-top:18px; padding-top:16px; border-top:1px solid var(--rule); font-size:14px; color:var(--ink-soft); }
.facts .patent .mono{ color:var(--ink); }
.timeline{ margin:40px 0 0; }
.timeline h3, .expertise h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 22px; }
.role{ display:grid; grid-template-columns:170px 1fr; gap:24px; padding:0 0 26px; }
@media (max-width:640px){ .role{ grid-template-columns:1fr; gap:6px; } }
.role .when{ font-family:"IBM Plex Mono", monospace; font-size:12.5px; color:var(--stone); padding-top:3px; }
.role .what h4{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.12rem; margin:0 0 2px; }
.role .what .org{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; color:var(--oxblood); font-weight:500; margin:0 0 8px; }
.role .what p{ margin:0; font-size:15.5px; color:var(--ink-soft); line-height:1.55; }
.expertise{ margin-top:40px; }
.tags{ display:flex; flex-wrap:wrap; gap:8px; margin:0; padding:0; list-style:none; }
.tags li{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--ink); background:var(--paper); border:1px solid var(--rule); border-radius:999px; padding:5px 13px; }

/* ---------- buttons / actions ---------- */
.doc-actions{ margin-top:26px; display:flex; flex-wrap:wrap; gap:12px; align-items:center; }
.btn{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; font-weight:500; text-decoration:none; border-radius:8px; padding:9px 16px; display:inline-block; }
.btn-primary{ background:var(--oxblood); color:#fff; border:1px solid var(--oxblood); }
.btn-primary:hover{ background:var(--oxblood-2); color:#fff; }
.btn-ghost{ background:transparent; color:var(--ink); border:1px solid var(--rule); }
.btn-ghost:hover{ border-color:var(--ink-soft); }

/* ---------- entry lead-in card ---------- */
.entry-card{ display:grid; grid-template-columns:minmax(0,1.55fr) minmax(0,1fr); gap:48px; align-items:start; }
@media (max-width:820px){ .entry-card{ grid-template-columns:1fr; gap:32px; } }
.abstract{ font-size:1.02rem; }
.abstract h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 14px; }
.abstract p{ margin:0 0 1em; }
.keywords{ margin-top:22px; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; color:var(--ink-soft); }
.keywords b{ color:var(--viridian); font-weight:600; }
.entry-meta{ background:var(--paper-2); border:1px solid var(--rule); border-radius:10px; padding:24px 26px; }
.entry-meta h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 16px; }
.entry-meta dl{ margin:0 0 4px; display:grid; grid-template-columns:auto 1fr; gap:11px 16px; }
.entry-meta dt{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; color:var(--stone); }
.entry-meta dd{ margin:0; font-size:15px; }

/* ---------- status panels (pending docs) ---------- */
.doc-frame{ margin-top:6px; border:1px solid var(--rule); border-radius:12px; overflow:hidden; background:var(--paper-2); }
.doc-embed{ width:100%; height:78vh; min-height:520px; border:0; display:block; background:#fff; }
.doc-pending{ display:flex; flex-direction:column; align-items:flex-start; gap:14px; padding:44px 40px; min-height:220px; justify-content:center; }
.status{ display:inline-flex; align-items:center; gap:9px; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.02em; color:var(--oxblood); background:var(--paper); border:1px solid var(--rule); border-radius:999px; padding:6px 14px; }
.status .dot{ width:8px; height:8px; border-radius:50%; background:var(--oxblood); box-shadow:0 0 0 4px rgba(108,34,51,.12); }
.doc-pending p{ margin:0; max-width:58ch; color:var(--ink-soft); }
.doc-pending .fname{ font-family:"IBM Plex Mono", monospace; font-size:13px; color:var(--ink); }

/* ---------- footer ---------- */
footer{ padding:56px 0 72px; }
.foot-grid{ display:grid; grid-template-columns:1.4fr 1fr; gap:40px; }
@media (max-width:640px){ .foot-grid{ grid-template-columns:1fr; gap:28px; } }
footer h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 14px; }
footer p{ margin:0 0 .8em; font-size:15px; color:var(--ink-soft); max-width:52ch; }
footer .contact a{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:15px; }
.disclosure{ margin-top:44px; padding-top:22px; border-top:1px solid var(--rule); font-size:13px; color:var(--stone); max-width:78ch; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; line-height:1.6; }

/* =============================================================
   LONG-FORM ARTICLE (entry.html)
   ============================================================= */
.paper-head{ border-bottom:1px solid var(--rule); }
.paper-head .wrap{ padding:64px 28px 46px; max-width:900px; }
.paper-head .kicker{ margin-bottom:20px; }
h1.paper-title{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:500; font-size:clamp(2rem,4.4vw,3.15rem);
  line-height:1.12; letter-spacing:-0.012em; margin:0 0 22px; max-width:26ch;
}
.paper-authors{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:15px; color:var(--ink); margin:0 0 4px; font-weight:500; }
.paper-affil{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; color:var(--stone); margin:0; }

article.paper{ max-width:720px; margin:0 auto; padding:52px 28px 80px; }
article.paper .abstract-block{
  background:var(--paper-2); border:1px solid var(--rule); border-radius:12px;
  padding:28px 30px; margin:0 0 40px;
}
article.paper .abstract-block h2{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600;
  letter-spacing:.04em; color:var(--viridian); margin:0 0 12px; text-transform:none;
}
article.paper .abstract-block p{ margin:0 0 .9em; font-size:1.01rem; }
article.paper .abstract-block .kw{ margin:14px 0 0; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; color:var(--ink-soft); }
article.paper .abstract-block .kw b{ color:var(--viridian); }

article.paper h2.sec{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.7rem; line-height:1.15;
  letter-spacing:-0.01em; margin:2.4em 0 .1em; padding-top:.5em; border-top:1px solid var(--rule);
}
article.paper h2.sec:first-of-type{ margin-top:0; }
article.paper h3.sub{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-style:italic; font-size:1.24rem;
  color:var(--oxblood); margin:1.8em 0 .2em;
}
article.paper p{ margin:0 0 1.15em; }
article.paper p.first{ margin-top:1em; }
article.paper sup{ font-size:.68em; line-height:0; color:var(--oxblood); font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; }

/* figures */
figure.fig{ margin:34px 0; padding:0; }
figure.fig img{ margin:0 auto; border:1px solid var(--rule); border-radius:6px; background:#fff; }
figure.fig.plain img{ border:none; background:transparent; }
figure.fig figcaption{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; line-height:1.5; color:var(--ink-soft);
  margin:12px 4px 0;
}
figure.fig figcaption b{ color:var(--ink); font-weight:600; }
figure.fig.wide{ /* let very wide figures use full article width */ }
pre.seqblock{
  font-family:"IBM Plex Mono", monospace; font-size:11.5px; line-height:1.45; color:var(--ink);
  background:var(--paper-2); border:1px solid var(--rule); border-radius:8px;
  padding:16px 18px; overflow-x:auto; margin:0; white-space:pre;
}
mark.motif{ background:rgba(53,105,90,.22); color:inherit; padding:0 1px; border-radius:2px; }

/* to-top / back link */
.paper-foot{ border-top:1px solid var(--rule); }
.paper-foot .wrap{ padding:34px 28px 60px; display:flex; flex-wrap:wrap; gap:16px; align-items:center; justify-content:space-between; }
.paper-foot .note{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--stone); max-width:60ch; }

/* =============================================================
   REFERENCES (references.html)
   ============================================================= */
.ref-tools{ max-width:820px; margin:0 auto; padding:28px 28px 0; }
.ref-filter{
  width:100%; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:15px; color:var(--ink);
  background:#fff; border:1px solid var(--rule); border-radius:9px; padding:12px 15px;
}
.ref-filter::placeholder{ color:var(--stone); }
.ref-count{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--stone);
  margin:12px 2px 0;
}
ol.reflist{
  max-width:820px; margin:22px auto 0; padding:0 28px 20px; list-style:none; counter-reset:ref;
}
ol.reflist li{
  counter-increment:ref; position:relative; padding:16px 0 16px 52px;
  border-bottom:1px solid var(--rule); font-size:15.5px; line-height:1.5; scroll-margin-top:80px;
}
ol.reflist li::before{
  content:counter(ref); position:absolute; left:0; top:17px; width:38px; text-align:right;
  font-family:"IBM Plex Mono", monospace; font-size:12.5px; color:var(--oxblood);
}
ol.reflist li:target{ background:var(--paper-2); border-radius:8px; }
ol.reflist li:target::before{ font-weight:600; }
.ref-cite{ color:var(--ink); }
.ref-links{ margin-top:6px; display:flex; gap:14px; }
.ref-links a{
  font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12px; letter-spacing:.01em;
  color:var(--viridian); text-decoration:none; border-bottom:1px solid transparent;
}
.ref-links a:hover{ border-bottom-color:var(--viridian); }
.ref-empty{ max-width:820px; margin:24px auto; padding:0 28px; color:var(--stone); font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:14px; }

/* clickable citation superscripts in the paper */
article.paper sup a{ color:inherit; text-decoration:none; }
article.paper sup a:hover{ text-decoration:underline; }

/* =============================================================
   AI ANALYSIS (analysis.html)
   ============================================================= */
.ai-note{
  max-width:720px; margin:0 auto; padding:0 28px;
}
.ai-note .callout{
  background:var(--paper-2); border:1px solid var(--rule); border-left:3px solid var(--viridian);
  border-radius:8px; padding:16px 18px; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif;
  font-size:13.5px; line-height:1.55; color:var(--ink-soft);
}
.ai-note .callout b{ color:var(--ink); }

/* scorecard */
.scorecard{ margin:30px 0 8px; border:1px solid var(--rule); border-radius:12px; overflow:hidden; }
.scorecard .sc-top{
  display:flex; align-items:baseline; justify-content:space-between; gap:16px;
  padding:18px 22px; background:var(--paper-2); border-bottom:1px solid var(--rule);
}
.scorecard .sc-top h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; font-weight:600; letter-spacing:.03em; color:var(--viridian); margin:0; }
.scorecard .sc-total{ font-family:"IBM Plex Mono",monospace; font-size:15px; color:var(--oxblood); }
.scorecard .sc-total b{ font-size:20px; }
.sc-row{ display:grid; grid-template-columns:1fr auto auto; align-items:center; gap:14px; padding:13px 22px; border-bottom:1px solid var(--rule); }
.sc-row:last-child{ border-bottom:none; }
.sc-row .sc-name{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:14.5px; color:var(--ink); }
.sc-dots{ display:inline-flex; gap:4px; }
.sc-dots i{ width:9px; height:9px; border-radius:50%; background:var(--rule); display:inline-block; }
.sc-dots i.on{ background:var(--oxblood); }
.sc-num{ font-family:"IBM Plex Mono",monospace; font-size:13px; color:var(--ink-soft); width:2.4em; text-align:right; }
@media (max-width:520px){
  .sc-row{ grid-template-columns:1fr auto; }
  .sc-dots{ display:none; }
}

/* mini scorecard on hub lead-in */
.score-mini{ margin:0; display:grid; grid-template-columns:auto 1fr; gap:9px 14px; align-items:center; }
.score-mini dt{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--ink-soft); }
.score-mini dd{ margin:0; font-family:"IBM Plex Mono",monospace; font-size:13px; color:var(--oxblood); }

article.paper h3.subn{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.18rem; margin:1.7em 0 .2em; color:var(--ink); }
article.paper ul, article.paper ol.body{ margin:0 0 1.15em; padding-left:1.25em; }
article.paper ul li, article.paper ol.body li{ margin:0 0 .5em; }
article.paper .lead-q{ font-style:italic; color:var(--ink-soft); }

/* works-cited list */
ol.worklist{ counter-reset:wc; list-style:none; margin:14px 0 0; padding:0; }
ol.worklist li{ counter-increment:wc; position:relative; padding:12px 0 12px 44px; border-bottom:1px solid var(--rule); font-size:14.5px; line-height:1.5; }
ol.worklist li::before{ content:counter(wc); position:absolute; left:0; top:13px; width:30px; text-align:right; font-family:"IBM Plex Mono",monospace; font-size:12px; color:var(--oxblood); }
ol.worklist a{ word-break:break-word; }

/* =============================================================
   INLINE PDF VIEWERS
   ============================================================= */
.pdf-viewer{ max-width:900px; margin:0 auto; padding:44px 28px 8px; }
.pdf-viewer.in-section{ padding:26px 0 0; max-width:none; }
.pdf-viewer h2{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.5rem; letter-spacing:-0.01em; margin:0 0 6px; }
.pdf-viewer .sub{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--stone); margin:0 0 16px; }
.pdf-frame{ width:100%; height:82vh; min-height:560px; border:1px solid var(--rule); border-radius:10px; background:var(--paper-2); display:block; }
.pdf-viewer.in-section .pdf-frame{ height:70vh; min-height:480px; }
.pdf-fallback{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--ink-soft); margin:10px 2px 0; }

/* =============================================================
   HYPOTHESIS OVERVIEW (hub)
   ============================================================= */
.hyp-grid{ max-width:760px; }
.keypoint{ border-left:3px solid var(--oxblood); background:var(--paper-2); border-radius:8px;
  padding:20px 24px; margin:26px 0 0; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:1.12rem; line-height:1.55; }
.keypoint b{ color:var(--oxblood); font-weight:600; }
.pillars{ background:var(--paper-2); border:1px solid var(--rule); border-radius:10px; padding:22px 24px; }
.pillars h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 14px; }
.pillars dl{ margin:0; display:grid; gap:14px; }
.pillars dt{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; font-weight:600; color:var(--ink); margin-bottom:2px; }
.pillars dd{ margin:0; font-size:14px; color:var(--ink-soft); line-height:1.5; }
.sources{ margin:34px 0 0; }
.sources h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:600; letter-spacing:.04em; color:var(--viridian); margin:0 0 12px; }
.sources ul{ list-style:none; margin:0; padding:0; display:grid; gap:9px; }
.sources li{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; line-height:1.5; color:var(--ink-soft); }
.sources li a{ color:var(--viridian); }

/* bulleted factor list inside hub prose */
.prose ul.factors{ margin:1.2em 0 0; padding-left:1.3em; list-style:none; }
.prose ul.factors li{ position:relative; margin:0 0 .8em; padding-left:1.1em; line-height:1.55; }
.prose ul.factors li::before{ content:"\2014"; position:absolute; left:0; color:var(--oxblood); }
.prose ul.factors li b i, .prose ul.factors li i b{ color:var(--oxblood); }

/* =============================================================
   BATTLE BIOTECH — app shell with persistent left sidebar
   ============================================================= */
.app{ display:flex; align-items:stretch; min-height:100vh; }
.sidebar{
  width:266px; flex:none; background:var(--ink); color:#d9d6dd;
  position:sticky; top:0; align-self:flex-start; height:100vh;
  display:flex; flex-direction:column; padding:28px 22px 22px;
}
.sidebar .bb-logo{ display:flex; align-items:baseline; gap:8px; margin:0 0 2px; }
.sidebar .bb-logo .name{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.5rem; letter-spacing:-.01em; color:#fff; }
.sidebar .bb-logo .dot{ width:9px; height:9px; border-radius:50%; background:var(--oxblood-2); display:inline-block; }
.sidebar .tagline{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:11.5px; letter-spacing:.02em; color:#9d98a5; margin:0 0 4px; }
.sidebar .ceo{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12px; color:#b9b4c0; margin:0 0 24px; }
.sidebar .ceo b{ color:#efedf1; font-weight:600; }
.side-nav{ list-style:none; margin:0; padding:0; display:flex; flex-direction:column; gap:2px; }
.side-nav li.grp{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:10px; font-weight:600; letter-spacing:.09em; text-transform:uppercase; color:#7f7a88; margin:18px 0 5px 12px; }
.side-nav a{ display:block; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13.5px; color:#cfccd4; text-decoration:none; padding:9px 12px; border-radius:8px; border-left:2px solid transparent; }
.side-nav a:hover{ background:rgba(255,255,255,.07); color:#fff; }
.side-nav a[aria-current="page"]{ background:rgba(255,255,255,.09); color:#fff; border-left-color:var(--oxblood-2); }
.sidebar .side-foot{ margin-top:auto; padding-top:20px; font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:11px; line-height:1.5; color:#8a8592; }
.sidebar .side-foot a{ color:#b9b4c0; }
.main{ flex:1 1 auto; min-width:0; }
.main > .wrap, .main .bb-wrap{ max-width:940px; margin:0 auto; padding:0 32px; }
@media (max-width:860px){
  .app{ flex-direction:column; }
  .sidebar{ width:auto; height:auto; position:sticky; top:0; z-index:60; flex-direction:column; gap:10px; padding:14px 18px; }
  .sidebar .tagline, .sidebar .ceo, .sidebar .side-foot, .side-nav li.grp{ display:none; }
  .side-nav{ flex-direction:row; flex-wrap:wrap; gap:4px; }
  .side-nav a{ padding:7px 10px; border-left:none; font-size:13px; }
}

/* ---- landing hero ---- */
.bb-hero{ padding:66px 0 26px; }
.bb-hero .eyebrow{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; font-weight:500; color:var(--viridian); display:flex; align-items:center; gap:10px; margin:0 0 20px; }
.bb-hero .eyebrow::before{ content:""; width:26px; height:2px; background:var(--viridian); display:inline-block; }
.bb-hero h1{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:400; font-size:clamp(2.3rem,5vw,3.9rem); line-height:1.04; letter-spacing:-.015em; margin:0 0 16px; max-width:20ch; }
.bb-hero h1 em{ font-style:italic; color:var(--oxblood); }
.bb-hero .mission{ font-size:1.14rem; color:var(--ink); max-width:60ch; margin:0 0 14px; }
.bb-hero .lede2{ color:var(--ink-soft); max-width:60ch; margin:0; }

/* ---- animated cell figure ---- */
.bb-figure{ margin:34px 0 8px; border:1px solid var(--rule); border-radius:14px; background:linear-gradient(180deg,#fbfbf8,#eef0ea); padding:14px 14px 8px; overflow:hidden; }
.bb-figure svg{ width:100%; height:auto; display:block; }
.bb-figure figcaption{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:12.5px; line-height:1.5; color:var(--ink-soft); padding:12px 8px 6px; }
.bb-figure figcaption b{ color:var(--ink); }
/* cell/exosome animation primitives */
.cellbody{ transform-origin:210px 232px; }
.exo{ }
.tauknot{ }
@media (prefers-reduced-motion: no-preference){
  .cellbody{ animation:bb-pulse 5.5s ease-in-out infinite; }
  .exo{ animation:bb-exo 6.5s linear infinite; opacity:0; }
  .tauknot.free{ animation:bb-tau 6.5s ease-in infinite; }
  .mvb{ animation:bb-drift 6s ease-in-out infinite; transform-origin:center; }
}
@keyframes bb-pulse{ 0%,100%{ transform:scale(1);} 50%{ transform:scale(1.015);} }
@keyframes bb-drift{ 0%,100%{ transform:translate(0,0);} 50%{ transform:translate(10px,-6px);} }
@keyframes bb-exo{ 0%{ transform:translateX(0); opacity:0;} 8%{ opacity:1;} 78%{ opacity:1;} 100%{ transform:translateX(330px); opacity:0;} }
@keyframes bb-tau{ 0%,58%{ transform:translate(0,0); opacity:1;} 82%{ opacity:1;} 100%{ transform:translate(16px,30px); opacity:0;} }

/* ---- program cards on landing ---- */
.programs{ display:grid; grid-template-columns:1fr 1fr; gap:18px; margin:40px 0 8px; }
@media (max-width:680px){ .programs{ grid-template-columns:1fr; } }
.pcard{ display:block; text-decoration:none; color:inherit; border:1px solid var(--rule); border-radius:12px; padding:22px 22px 20px; background:var(--paper-2); transition:border-color .15s, transform .15s; }
.pcard:hover{ border-color:var(--oxblood); transform:translateY(-2px); }
.pcard .k{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:11px; font-weight:600; letter-spacing:.06em; text-transform:uppercase; color:var(--viridian); margin:0 0 8px; }
.pcard h3{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:600; font-size:1.3rem; margin:0 0 6px; color:var(--ink); }
.pcard p{ margin:0; font-size:14.5px; color:var(--ink-soft); line-height:1.5; }
.pcard .go{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-size:13px; color:var(--oxblood); margin-top:12px; display:inline-block; }
.bb-section{ padding:8px 0 60px; }
.bb-section h2{ font-family:Inter, system-ui, -apple-system, "Segoe UI", Roboto, sans-serif; font-weight:500; font-size:1.9rem; letter-spacing:-.01em; margin:34px 0 10px; }
.bb-section p{ max-width:64ch; color:var(--ink-soft); }

/* =============================================================
   PROFESSIONAL TYPOGRAPHIC OVERRIDES (Inter)  — Annovis-style
   ============================================================= */
body{ -webkit-font-smoothing:antialiased; letter-spacing:-.002em; }
h1.title, .bb-hero h1, .paper-head h1.paper-title{ font-weight:700; letter-spacing:-.022em; }
h1.title em, .bb-hero h1 em{ font-style:normal; }         /* upright accent, not italic */
.hero .subtitle{ font-style:normal; font-weight:500; color:var(--ink-soft); }
.sec-head h2, .bb-section h2, article.paper h2.sec, .pdf-viewer h2{ font-weight:700; letter-spacing:-.015em; }
.pcard h3, .role .what h4, article.paper h3.sub, article.paper h3.subn,
.abstract h3, article.paper .abstract-block h2, .entry-meta h3, .facts h3,
.pillars h3, .sources h3, footer h3{ font-weight:600; }
.brand, .sidebar .bb-logo .name{ font-weight:700; letter-spacing:-.01em; }
.kicker, .eyebrow, .sec-index, nav.primary a{ font-weight:600; }
.sec-head .lede, .bb-hero .lede2{ font-style:normal; }

/* cleaner, flatter buttons */
.btn{ font-weight:600; letter-spacing:.005em; }
.btn-primary{ box-shadow:none; }

/* subtle section rhythm on white */
section.block{ border-bottom:1px solid var(--rule); }

/* header virion mark */
.bb-logo{ align-items:center; }
.bb-mark{ width:27px; height:27px; flex:none; display:block; }

/* detailed virion hero image */
.hero-virion{ display:block; width:min(320px,72%); height:auto; margin:34px 0 6px; }
@media (max-width:600px){ .hero-virion{ margin:26px auto 6px; } }